Until 26 April 2021, the city had 49 cumulative confirmed cases of COVID-19, all of those having recovered, and no deaths from the disease. The city saw nine more cases by 4 February, but no more cases until 15 March, when imported cases began to appear. The first case of the disease in Macau was confirmed on 22 January 2020, originating the COVID-19 pandemic in Macau. On 5 February, after a five-day strike by front-line medical workers, the Hong Kong government closed all but three border control points – Hong Kong International Airport, Shenzhen Bay Control Point, and Hong Kong–Zhuhai–Macau Bridge Control Point remaining open. Confirmed cases were generally transferred to Princess Margaret Hospital's Infectious Disease Centre for isolation and centralized treatment. The virus was first confirmed to have spread to Hong Kong on 23 January 2020, thus originating the COVID-19 pandemic in Hong Kong.

By 29 January, the virus was found to have spread to all provinces of mainland China. On 8 January 2020, a new coronavirus ( SARS-CoV-2) was identified as the cause of the pneumonia by Chinese scientists. It was first reported to the local government on 27 December 2019, and published on 31 December. The first wave of the disease manifested as the 2019–2020 COVID-19 outbreak in mainland China, beginning with a cluster of mysterious pneumonia cases, mostly related to the Huanan Seafood Market, in Wuhan, the capital of Hubei province. China was the first country to experience an outbreak of the disease, the first to impose drastic measures in response (including lockdowns and face mask mandates), and one of the first countries to bring the outbreak under control. The COVID-19 pandemic in China is part of the worldwide pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

China covid spike